帕雷科西布和横腹平面阻断对术后焦虑和认知的影响:一项随机对照试验
Fuzhen Zhang1, Chengzhi Wang2, Kan Li3
1Department of Anaesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
JPMA. The Journal of the Pakistan Medical Association..
|July 23, 2025
概括
帕雷科克西布在接受腹腔镜肠道手术的老年患者中有效降低了术后焦虑. 横向腹部平面阻塞在这个患者群体中没有显著影响焦虑或早期认知功能.
科学领域:
- 麻醉学 麻醉学
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 在接受重大手术的老年患者中,术后焦虑和认知功能障碍是很大的问题.
- laparoscopic肠道手术虽然侵袭性最小,但仍然可以引发这些不良影响.
- 有效的药理和区域麻醉技术对于改善患者的治疗结果至关重要.
研究的目的:
- 评估帕雷科克西布和横腹平面 (TAP) 阻断在治疗术后焦虑症方面的疗效.
- 评估这些干预措施对接受腹腔镜肠道手术的老年患者早期认知功能的影响.
- 为了比较帕雷科克西布,TAP阻断剂及其组合与对照组的影响.
主要方法:
- 一个多中心,随机对照试验,涉及205名老年患者 (60-85岁),计划进行选择性腹腔镜肠道手术.
- 患者被随机分为四组:对照组 (盐水),帕雷科克西布,TAP阻断剂,以及帕雷科克西布和TAP阻断剂的组合.
- 焦虑水平在手术前和手术后24小时和7天被评估. 血清瘤缩因子-α (TNF-α) 水平在特定时间点测量.
主要成果:
- 与对照组相比,帕雷科西布和组合组在手术后24小时显示出明显较低的焦虑评分 (p<0.05).
- 血清TNF-α度在手术后30分钟与对照组相比,在帕雷科克西布和组合组中显著降低 (p<0.05).
- 横腹腹平面块本身并没有显示出对术后焦虑或认知功能的显著影响.
结论:
- 帕雷科克西布在接受腹腔镜肠道手术的老年患者中有效缓解术后焦虑.
- 一个横向腹部平面块在这个人群中不会显著影响术后焦虑或早期认知功能.
- 这些发现表明,帕雷科克西布作为一种潜在的治疗药物,可以在这种手术背景下控制焦虑.
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