来自胡卜叶的三聚胺 (Diospyros kaki L.f.) 在实验动物中表现出抗2型糖尿病的作用和无毒性
Hung Van Nguyen1,2, Ha Thu Thi Nguyen1, Nhan Trong Le3
1Faculty of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam.
Basic & clinical pharmacology & toxicology
|July 23, 2025
概括
胡桃叶提取物 (Tri DKL) 在动物研究中没有显示出毒性. 这种天然化合物有效降低了2型糖尿病小鼠的血糖,胆固醇和甘油三水平,表明了治疗潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 自然产品化学 自然产品化学
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 目前对T2DM的治疗可能会产生显著的副作用.
- 自然产品正在越来越多地探索它们在治疗T2DM中的治疗潜力.
研究的目的:
- 评估桃叶 (Tri DKL) 中的一种三类提取物的安全性.
- 研究Tri DKL在2型糖尿病小鼠模型中的抗糖尿病和降脂作用.
主要方法:
- 在瑞士小鼠中评估了急性口服毒性.
- 在90天的时间内,在Wistar大鼠中评估了亚慢性毒性.
- 在瑞士小鼠中,使用高脂肪饮食和链毒素诱导了2型糖尿病.
- 糖尿病小鼠接受了2周的Tri DKL (250和750毫克/公斤/天) 治疗.
主要成果:
- 在高达2500毫克/体重的剂量下,Tri DKL没有表现出急性或亚慢性毒性.
- 在老鼠中,慢性服药并没有改变血液学参数或肝/功能.
- 在糖尿病小鼠中,Tri DKL显著降低了血糖,总胆固醇和肝脏甲水平.
- 治疗Tri DKL改善了肝脏和胰腺组织学,并降低了250 mg/kg体重的甘油三水平.
结论:
- 在动物模型中,Tri DKL是安全的,并且耐受性很好.
- Tri DKL 显示出显著的低血糖和降脂效应.
- 胡桃叶提取物显示出作为2型糖尿病管理的天然治疗剂的前景.
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