在南非,基于社区的差异化抗逆转录病毒疗法交付计划中的长期使用模式和临床结果
Lara Lewis1,2, Yukteshwar Sookrajh3, Johan van der Molen1
1Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
Journal of the International AIDS Society
|July 23, 2025
概括
南非的社区抗逆转录病毒疗法 (ART) 提供显示了多样化的使用模式,但良好的临床结果. 促进社区一致的ART使用可以减少患者的护理损失,并保持病毒抑制.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 艾滋病毒/艾滋病研究研究
背景情况:
- 关于为艾滋病毒感染者 (PLHIV) 提供差异化抗逆转录病毒疗法 (ART) 方案的长期实施和结果的数据有限.
- 这项研究分析了南非社区ART计划中的使用模式和治疗结果,持续了3.5年.
研究的目的:
- 分析社区ART交付的使用模式.
- 评估相关的治疗结果,包括护理损失和病毒性血.
- 评估社区ART使用对患者保留和病毒抑制的影响.
主要方法:
- 在南非克瓦祖鲁-纳塔尔州 (2016年10月 - 2019年3月) 的社区ART符合条件的第一线ART上对PLHIV进行回顾性队列研究.
- 以小组为基础的轨迹建模,以描述社区ART使用模式后转介.
- 对失去护理和对病毒性病评估的后勤回归进行生存分析.
主要成果:
- 超过8万名符合条件的患者,61.8%被转介到社区ART.
- 社区ART使用模式各不相同:42%持续使用,15%返回诊所,43%波动.
- 社区ART使用与36%的护理损失风险降低和3%的病毒病概率降低与10%的使用增加相关.
结论:
- 社区ART交付表明患者参与度不同,但产生了有利的临床结果.
- 持续的社区ART使用可以减少诊所负担,并减少失去了护理的患者的发生率.
- 促进持续的社区ART使用对于保持PLHIV病毒抑制至关重要.
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