在癌症中氧化应激和表观遗传重编程之间的相互作用
Xuejiao Ma1, Wei Fan2,3, Tao Zhang4,5
1West China School of Basic Medical Sciences & Forensic Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
International journal of cancer
|July 23, 2025
概括
氧化应激和表观遗传重编程是癌症的关键特征. 本综述详细介绍了这些过程如何相互影响,影响癌症的发展和免疫规避.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 氧化应激,细胞氧化还原状态的不平衡以及表观遗传重编程,即没有DNA变化的遗传基因表达变化,是癌症的标志.
- 越来越多的证据将氧化应激与表观遗传修饰联系起来,如DNA甲基化,基因质突变和非编码RNA调节.
- 表观遗传变化还可以通过影响线粒体功能和抗氧化基因表达来调节氧化应激.
研究的目的:
- 审查氧化应激和癌症中的表观遗传重编程之间的复杂交叉机制.
- 突出这些过程在致癌过程中的相互调节作用.
- 为了阐明它们在癌症免疫逃脱中的参与.
主要方法:
- 文献综述和现有关于氧化应激和癌症表观遗传学的研究的综合.
- 分析研究研究的分子链接之间的氧化还原平衡和表观遗传机械.
- 检查连接这些途径与瘤启动和免疫逃避的证据.
主要成果:
- 氧化应激直接影响DNA甲基化,基因素修饰和非编码RNA表达,从而改变癌细胞表观基因组.
- 表观遗传机制,包括线粒体DNA/RNA甲基化和线粒体电子运输链 (Mito-ETC) 基因的调节,影响细胞氧化应激水平.
- 氧化应激和表观遗传学之间的相互作用是癌症发展和瘤逃避免疫监测的能力的重要驱动因素.
结论:
- 氧化应激和表观遗传重编程之间的双向关系是癌症生物学的基础.
- 准这种交叉通话为癌症治疗和克服免疫抵抗提供了潜在的治疗策略.
- 对这些相互连接的途径的进一步研究对于推进癌症治疗至关重要.
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