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肠道和心血管疾病的疾病
Samuel C Delk1,2, Srinivasa T Reddy1,2,3, Alan M Fogelman1
1Division of Cardiology, Department of Medicine.
Current opinion in lipidology
|July 23, 2025
概括
肠道微生物群和托代谢显著影响心血管疾病风险. 改变肠道中的5-基三胺 (血清素) 途径可以减少动脉样硬化进展.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 心血管疾病 (CVD) 的发病因子越来越多地与肠道健康有关.
- 肠道微生物群及其代谢产物在全身炎症和代谢过程中起着至关重要的作用.
研究的目的:
- 审查最近关于肠道在心血管疾病中的作用的文献.
- 研究肠道托代谢和微生物群对动脉样硬化的影响.
主要方法:
- 与心血管事件相关的便微生物群和脂多糖化物 (LPS) 水平的分析.
- 使用Ldlr-/-小鼠养高脂肪,高胆固醇饮食 (HFD+HCD) 来模拟动脉样硬化.
- 在小鼠中研究了因多胺-2,3-二氧化酶1 (IDO1) 缺乏和5-西胺 (5-HT) 途径抑制的影响.
主要成果:
- 便微生物群和LPS模式预测了未来的心血管事件.
- 高脂肪饮食增加了肠道的IDO1活性,减少了诸如丁酸盐和血清素之类的有益代谢物.
- 在小鼠中,IDO1缺乏或5-HT通路抑制改善了肠道屏障功能,减少了炎症和降低了动脉样硬化.
结论:
- 肠道托代谢和微生物群衍生产品对动脉样硬化发展至关重要.
- 准肠道5-HT通路为心血管疾病提供了潜在的治疗策略.
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