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Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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旅行者腹 - 巩固我们的知识库.

Thomas H A Samuels1,2, Clare E Warrell1,3

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概括
此摘要是机器生成的。

旅行者腹是常见的,轻微的病例频繁. 诊断和微生物组研究的进步提供了新的见解,但关于抗菌素耐药性的严重程度和日益增长的共识仍然是挑战.

关键词:
抗微生物耐药性 抗微生物耐药性微生物组是一个微生物组.旅行 旅行 医学 旅行 医学旅行者的腹旅行者的腹

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科学领域:

  • 传染性疾病 传染性疾病
  • 胃肠病学 胃肠病学
  • 公共卫生 公共卫生

背景情况:

  • 旅行者腹 (TD) 是国际旅行者中普遍存在的疾病.
  • 对TD的有效预防和管理策略尚未得到充分确立.
  • 最近的研究突出了TD不断变化的方面,包括流行病学,诊断和治疗.

研究的目的:

  • 审查最近流行病学,诊断和旅行者腹管理方面的进展.
  • 专注于新的严重性定义,分子诊断,抗菌素耐药性和感染后并发症.
  • 确定未来在 TD 中进行研究和干预的关键领域.

主要方法:

  • 关于旅行者腹的最新研究的文献综述.
  • 分析有关发病率,病原体和诊断方法的数据.
  • 评估当前和新兴的治疗和预防策略.

主要成果:

  • 旅行者腹发病率仍然很高,通常是轻微的,病毒病例越来越多地通过分子诊断来确定.
  • 微生物组研究表明,TD和抗生素使用后出现了显著的干扰.
  • 存在新的严重性定义,但缺乏共识;非吸收性抗生素和益生菌显示出希望,但抗菌素耐药性正在增加.
  • 感染后刺激性肠综合征 (IBS) 影响了一些患者的康复.

结论:

  • 在开发新疫苗和治疗方法方面,就TD严重程度定义达成共识至关重要.
  • 优先事项包括对抗菌素耐药性的监测,微生物组研究以及益生菌和疫苗的开发.
  • 需要更好地了解TD病理生理学和新的干预措施来解决TD后的IBS.