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组织病理学和分子证据表明,与胃肠道瘤相关的分子中存在恶性潜力

Diana Agostini-Vulaj¹, Zoltan N Oltavi¹, Xiaoyan Liao²

¹Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY, 14642, USA.

Virchows Archiv : an international journal of pathology

|July 23, 2025

概括

胃肠腺瘤中的甲状腺细胞 (SM) 和微癌细胞 (MC) 代表具有Wnt/β-catenin激活的干细胞谱. 这些病变表现出多血统分化潜力,很少会发展为恶性瘤.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
分子病理学分子病理学

背景情况:

状细胞 (SM) 和微癌细胞 (MC) 是 GI 腺瘤中不同的固体细胞群.
尽管它们被认为是良性的,但它们的生物发生和恶性潜力仍在争论中.

研究的目的:

描述GI瘤的组织形态学,免疫特征和分子特征.
调查这些病变中恶性进展的可能性.

主要方法:

对39个带有的胃肠道瘤进行了回顾性审查.
组织形态学分类,免疫组织化学分析 (β-catenin,CD10,CK5,INSM1,CDX2,SATB2,p63,synaptophysin,Ki67) 进行.
对常见突变 (KRAS,PIK3CA,APC) 的分子分析.

主要成果:

在SM和MC中,核β-catenin,CD10,CK5,INSM1,CDX2和SATB2.2的表达高.
类似SM的分子表达p63的频率更高,而类似MC的分子表达synaptophysin的频率更高.
克拉斯,PIK3CA和APC是最常见的突变;质藏着类似的或更多的突变比背景瘤.
8例结肠直肠病 (31%) 呈侵袭性,其中1例进展为不分化癌.

结论:

SM和MC代表具有Wnt/β-catenin激活和分化可塑性的基础干细胞的光谱.
这些病变在罕见情况下具有恶性进展的潜力.
了解它们的分子驱动因素对于评估风险和指导管理至关重要.

关键词:

胃肠道胃肠道胃肠道这是入侵的入侵.这是一种微型癌细胞.新生病是什么?新生病新生病是什么?形形形形形形

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