相关实验视频

Updated: Sep 14, 2025

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization

Published on: January 20, 2023

肺纤维化和外体:治疗的途径

R J Nija¹, T G Nithya²

¹Department of Biochemistry, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India.

Molecular biology reports

|July 23, 2025

概括

小细胞外囊泡 (sEVs) 是肺纤维化中的关键参与者,影响疾病的进展. 外体细胞通过调节纤维化通路并促进修复,对异常性肺纤维化 (IPF) 具有治疗前景.

科学领域:

肺部医学肺部医学
细胞生物学细胞生物学
生物技术是生物技术.

背景情况:

异常性肺纤维化 (IPF) 是一种由细胞外基质 (ECM) 沉积和纤维细胞激活过度驱动的渐进性肺病.
关键的信号通路 (TGF-β,WNT/β-catenin,PI3K/AKT,YAP/TAZ) 和上皮-介质细胞过渡 (EMT) 都与IPF的发病有关.
包括外体在内的小型细胞外囊泡 (sEV) 越来越多地被认为是纤维化微环境的关键调解者.

研究的目的:

审查肺纤维化分子机制,强调外体交叉的作用.
在IPF中探索外体和工程化纳米粒子-外体混合体的治疗潜力.
整合最近关于纤维细胞异质性,衰老相关分泌表型 (SASP) 和动物模型局限性的发现.

主要方法:

文献综述侧重于IPF的分子机制和治疗策略.
对研究SEVs和外体在纤维性肺部疾病中的作用的分析.
结合了来自单细胞RNA测序 (scRNA-seq) 和衰老研究的见解.

主要成果:

外体调节纤维细胞的行为,免疫信号和纤维化肺中的组织重塑.
外体和基于外体的杂交体显示出向纤维化通路和促进组织修复的潜力.
纤维细胞异质性和SASP影响外体载荷和IPF进展.

结论:

外基因交叉是肺纤维化发展和进展的中心机制.
基于外体的疗法为IPF的精准医学方法提供了一个有希望的途径.
需要进一步的研究,以克服慢性IPF复述现有的动物模型的局限性.

关键词:

在EMT中,EMT是EMT.最终MT 结束MT 外基因组是外基因组的组成部分.肺部纤维化肺部纤维化

更多相关视频

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

Published on: June 20, 2025

相关概念视频

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

Cystic Fibrosis: Pathogenesis

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Cystic Fibrosis: Management

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...