在青春期早期,体重增加,年龄和皮下微观结构的明显模式
Shana Adise1, Zhaolong Adrian Li2, Jonatan Ottino-González1
1Division of Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California.
JAMA network open
|July 23, 2025
概括
在青少年女性中,较高的限制性正常化同位素 (RNI) 值与不健康的体重增加有关,可能表明神经炎症. 这表明RNI可能是肥胖相关的大脑变化的早期指标.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 放射学 放射学是一门学科.
背景情况:
- 儿童肥胖与大脑的微观结构差异有关.
- 性别特定的体重增加在这些关联中的作用尚不清楚.
- 限制光谱成像 (RSI) 使用水扩散测量大脑的微结构健康,限制的正常化同位素 (RNI) 隔间反映细胞性.
研究的目的:
- 调查RNI值,神经发育和青春期早期体重增加之间的关联.
- 探索这些关系中的潜在的性别差异.
主要方法:
- 使用青少年大脑认知发展 (ABCD) 研究数据进行的纵向队列研究.
- 线性混合效应模型分析了RNI,年龄和BMI (体重指数) 在16个控制食欲的大脑区域之间的双向关联.
- 根据性别和体重分层的分析:稳定状态与体重变化状态.
主要成果:
- 在体重稳定的年轻人中,RNI值与年龄相关,但BMI无关.
- 在不同体重增加的年轻人中,RNI值显示了与皮层下区域BMI的双向关联,独立于年龄.
- 较高的RNI值与女性的BMI随着时间的推移增加密切相关,但男性没有.
结论:
- RNI值与年龄和BMI有关,较高的值可能表明神经炎症.
- 升高的RNI可能标志着与不健康的体重增加相关的神经炎症过程.
- RNI缩放因子可以作为青少年,特别是女性中与肥胖相关的神经发育变化的早期指标.
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