蛋白质错误折叠和聚合是慢性疼痛和神经退行性疾病之间的机制联系
Nebojsa Brezic1,2, Strahinja Gligorevic1,2, Aleksandar Sic1,2
1Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA.
Current issues in molecular biology
|July 23, 2025
概括
慢性疼痛可能通过促进蛋白质错折和神经炎症来加速神经退行性疾病. 针对蛋白质聚合和炎症可以为疼痛管理和疾病修饰提供双重好处.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 慢性疼痛影响全球30-50%的成年人,持续超过正常治愈.
- 神经退行性疾病 (NDs) 涉及由于蛋白质错折导致的神经元损失和认知/运动衰退.
- 新出现的证据表明慢性疼痛和神经炎症之间存在联系,反映了ND过程.
研究的目的:
- 探索蛋白质错误折叠和聚合桥梁慢性疼痛和神经退行症的假设.
- 系统地审查分子通路,蛋白质稳定功能障碍和共享的神经免疫机制.
- 为了确定针对这个交叉点的潜在治疗策略.
主要方法:
- 对蛋白质错折的分子途径进行系统的审查.
- 在慢性疼痛中检查蛋白质稳定性功能障碍.
- 在慢性疼痛和NDS中分析共享的神经免疫机制.
主要成果:
- 蛋白质错误折叠和聚合可能充当慢性疼痛和无线性疼痛之间的机械联系.
- 慢性疼痛与神经炎症,氧化应激和错误折叠的蛋白质的类传播有关.
- 有证据表明,慢性疼痛与加速的神经退行性病理有关,包括tau和粉样蛋白失调.
结论:
- 针对蛋白质聚合,伴侣功能,UPR和质激活的干预措施可以缓解慢性疼痛和缓慢的神经退行.
- 了解慢性疼痛和NDS的交叉点,为新的治疗方法开辟了道路.
- 调节蛋白质稳定和炎症可以为疼痛和神经退行性疾病管理提供双重好处.
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