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解码肝细胞癌转移:分子机制,向疗法和潜在的生物标志物

Ke Wei¹, Chunxiu Peng¹, Yangzhi Ou¹

¹State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Current issues in molecular biology

|July 23, 2025

概括

肝细胞癌 (HCC) 转移是由遗传,表观遗传和基因组变化驱动的. 本综述涵盖了高级HCC的分子驱动因素,疗法和生物标志物,以改善患者的治疗结果.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
瘤转移显著恶化HCC患者的预后和生存率.
了解HCC转移的分子机制对于开发有效的治疗方法至关重要.

研究的目的:

综合审查推动HCC转移的分子事件.
突出三维基因组结构在HCC进展中的作用.
总结针对高级HCC的向疗法和生物标志物的最新进展.

主要方法:

在HCC转移中的分子机制的文献综述.
对遗传突变,表观遗传改变和信号通路的分析.
检查3D基因组结构,向疗法和生物标志物.

主要成果:

关键的分子驱动因素包括遗传突变,表观遗传变化和改变的信号通路.
三维基因组重建在HCC发病和转移中起着至关重要的作用.
新兴的生物标志物 (CTC,ctDNA,外体) 显示出早期检测和监测的前景.

结论:

综合的分子洞察力和临床应用对于推动HCC转移研究至关重要.
向疗法正在改善晚期HCC的结果,特别是在控制转移方面.
生物标志物为改善诊断,预后和治疗反应评估提供了潜力.

关键词:

生物标志物生物标志物肝细胞癌是肝细胞癌.转移转移转移转移分子机制的分子机制.信号通道的信号通道.有针对性的治疗.

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