随着时间的推移,DNA甲基化趋势在发育期和无发育期的年轻女性之间
Su Chen1, John W Holloway2,3, Wilfried Karmaus4
1Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Epigenomes
|July 23, 2025
概括
怀孕可能会随着时间的推移改变DNA甲基化 (DNAm) 模式. 一些DNAm变化在分娩时加速,而其他变化在与无产妇对照组相比,在产妇妇女中减缓或停止.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生殖健康 生殖健康
- 基因组学就是基因组学.
背景情况:
- 怀孕和分娩对母亲的健康有长期影响,对各种疾病具有保护性和增加风险的影响.
- 在怀孕后,驱动这些改变疾病风险的潜在生物机制在很大程度上是未知的.
- 基因甲基化 (DNAm) 是一种关键的表观遗传机制,它调节基因表达,并可能在调解这些长期健康影响方面发挥作用.
研究的目的:
- 为了研究从怀孕前到分娩后的DNA甲基化的纵向变化.
- 为了比较 DNA 甲基化动态在 parous 妇女 (那些已经分娩) 与 nulliparous 控制 (那些没有).
- 为了确定与怀孕和分娩相关的特定DNA甲基化模式.
主要方法:
- 纵向研究设计跟踪DNA甲基化变化随着时间的推移.
- 分析了180个与parous相关的CpG位点 (基因组中甲基化发生的位置).
- 应用线性混合效应模型与重复测量,以比较18至26岁的孕妇和无孕妇之间的甲基化变化,包括怀孕前,怀孕和怀孕后的时期.
主要成果:
- 基因组甲基化变化一般遵循类似的方向趋势 (主要是下降) 在和无组.
- 大约一半的CpG变化在孕期妇女中显示出较小的甲基化变化,而另一半与无孕期对照相比显示出更大的变化.
- 一个显著的CpG子集 (9%) 显示的变化仅在无孕妇女,导致明显的甲基化水平在孕妇女26岁.
结论:
- 怀孕和分娩可以影响DNA甲基化变化的速率.
- 这些效应可以在某些基因组区域表现为加速甲基化变化.
- 相反,怀孕也可能随着时间的推移减缓或停止其他区域的甲基化变化.
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