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Updated: Sep 14, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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通过DNA模块化接体进行编程向蛋白质降解

Xuanming Teng1, Jingyi Yang1, Zhiyi Ren1

  • 1School of Pharmacy, Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.

ChemMedChem
|July 23, 2025
PubMed
概括

这项研究介绍了DNA-PROTACs,一种对蛋白质降解的模块化方法. 这种方法简化了针对治疗开发的蛋白质溶解向嵌合体 (PROTACs) 的设计和选.

关键词:
在DNA模块化过程中.自组装DNA的自我组装.这就是 PROTACs.有针对性的蛋白质降解降解.

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