ChronobioticsDB:药物和化合物调节昼夜节律的数据库
Ilya A Solovev1, Denis A Golubev1, Arina I Yagovkina1
1Laboratory of Translational Bioinformatics and Systems Biology, Medical Institute, Pitirim Sorokin Syktyvkar State University, Oktyabrsky Prosp. 55, 167000 Syktyvkar, Russia.
Clocks & sleep
|July 23, 2025
概括
这项研究介绍了ChronobioticsDB,这是Chronobiotics的第一个全面的在线数据库,这些是调节昼夜节律的物质. 该数据库旨在为时代生物学和药物信息学研究人员整合这些多样化化合物的信息.
科学领域:
- 时间生物学 时间生物学
- 药物信息学 是一种信息学.
- 生物信息学是一种生物信息学.
背景情况:
- 时代生物制剂,调节昼夜节律的物质,在药理上是多样化的,包括天然化合物,合成调节剂,催眠药和激素.
- 尽管有悠久的历史,但缺乏统一的分类和全面的知识库,用于chronobiotics.
- 现有的分类是分散的,阻碍了研究和临床应用.
研究的目的:
- 开发世界上第一个精心策划的,持续更新的,公开可访问的在线数据库.
- 通过创建一个集中资源来解决时代生物知识的碎片化问题.
- 为了支持时代生物学,时代医学和药物信息学方面的进步.
主要方法:
- 使用Django框架和PostGreSQL构建一个关系数据库ChronobioticsDB.
- 从主要的科学文献数据库 (PubMed,Google Scholar,Scopus,Web of Science) 提取数据并进行手动注释.
- 与外部化学和生物数据库 (ChemSpider,DrugBank,UniProt,FDA) 进行集成,以全面丰富数据.
主要成果:
- 开发一个关系数据库,ChronobioticsDB,具有Web接口.
- 每个chronobiotic条目包括详细的化合物信息,分子结构,SMILES,IUPAC名称和链接到主要来源.
- 与多个外部数据库的同步确保了数据的完整性和准确性.
结论:
- ChronobioticsDB为时代生物学和相关领域的研究人员和从业人员提供了一个强大的,多方面的资源.
- 该数据库有助于更深入地了解时代生物化合物及其机制.
- 这一举措是朝着统一理解和应用慢生菌学迈出的重要一步.
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