痴呆症和骨质疏松症之间的潜在生物和遗传联系:一个范围审查
Abayomi N Ogunwale1, Paul E Schulz1, Jude K des Bordes1
1UTHealth McGovern Medical School, Houston, TX 77030, USA.
Geriatrics (Basel, Switzerland)
|July 23, 2025
概括
像Dkk1和OPG这样的骨生物标志物与骨质疏松症和痴呆症有关. 最近的研究并不支持APOE4作为女性这两种疾病的直接遗传原因.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物化学 生化学
背景情况:
- 骨质疏松症和痴呆症之间的生物联系在很大程度上是未知的.
- 调查共同的遗传和生物因素对于理解这些普遍的退行性疾病至关重要.
研究的目的:
- 进行临床研究的范围审查.
- 确定与骨质疏松症和痴呆症相关的遗传和生物因素.
- 探索连接机制和途径.
主要方法:
- 在多个数据库 (Medline,Embase,PsycINFO,Cochrane,Web of Science,Google Scholar) 中搜索相关研究.
- 包括对痴呆症或骨质疏松症遗传因素或生物标志物的临床研究.
- 在1993年7月至2025年3月期间发表的英语精选同行评审研究,遵循PRISMA-ScR指南.
主要成果:
- 审查了23项研究,检查了诸如APOE多态/单基因,TREM2突变和粉样β等因素.
- 骨生物标志物 (DKK1,OPG,TRAIL) 被确定为潜在的认知变化的预测因素.
- 细胞外囊泡被认为是潜在的骨脑沟通通道.
结论:
- 在Wnt/β-Catenin和RANKL/RANK/OPG途径中的骨生物标志物在阿尔茨海默病 (AD) 和骨质疏松症中显示出一致的参与.
- 目前的证据不支持APOE4作为女性两种疾病的因果遗传联系.
- 粉样β毒性的骨质疏松症中的作用需要进一步的临床验证.
相关概念视频
Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
Dementia
167
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
167
Human Genetics
730
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
730
Psychoneuroimmunology: Diabetes and Cancer
62
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
62
Role of Vitamins in Maintaining Bone Health
3.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.7K
Alzheimer's Disease: Overview
669
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
669


