失去IgA和IgM会影响结构分离的SARS-CoV-2变种的广泛中和
Yalcin Pisil1, Tomoyuki Miura1, Kiyoki Ito2
1Laboratory of Primate Model, Research Center for Infectious Diseases, Institute for Life and Medical Science, Kyoto University, Kyoto 615-8530, Japan.
Antibodies (Basel, Switzerland)
|July 23, 2025
概括
随着时间的推移,mRNA疫苗后的抗体反应会减弱,IgA和IgM的下降会影响对SARS-CoV-2变种的中和幅度. 保持多样化的抗体同型是广泛免疫的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在SARS-CoV-2 mRNA疫苗接种后,中和抗体的耐用性和范围需要进一步调查.
- 了解抗体同型组合如何随时间变化影响对各种病毒变异的中和是至关重要的.
研究的目的:
- 在mRNA疫苗接种后,研究抗体同型组合的纵向变化.
- 评估这些变化对对抗结构多样化的SARS-CoV-2变异的中和的影响.
主要方法:
- 一个月 (1 mpv) 和接种疫苗后三个月 (3 mpv) 的mRNA疫苗接种血清分析.
- 使用了活病毒中和试验,酶相关免疫吸收试验 (ELISA) 和免疫黄金电子显微镜.
- 评估抗体标位,同型水平 (IgA,IgM,IgG) 和病毒形态.
主要成果:
- 中和标位下降了3mpv,特别是在对抗免疫逃避变体时.
- 兰巴达变种对早期血清表现出独特的敏感性,具有更广泛的病毒大小异质性.
- 随着时间的推移,IgA和IgM水平下降,而IgG保持更持久;IgA和IgM在减少尖峰密度下表现出更强的结合.
结论:
- 降低IgA和IgM水平会损害对Lambda等结构分歧的SARS-CoV-2变种的中和宽度.
- 维持动态,多价抗体同型反应,适应多种尖峰形态,对于广泛的跨变体免疫来说至关重要.
相关概念视频
01:36Humoral Immune Responses
76.4K
Overview
76.4K
01:26Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
01:29Immune Response Against Viral Pathogens
928
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
928
01:22Development of Immunocompetence
451
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
451
01:10Antibody Structure
61.3K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
61.3K