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葡萄牙的mpox监测和实验室反应:从三次疫情浪潮 (2022-2025) 中吸取教训
Rita Cordeiro1,2, Rafaela Francisco1,3, Ana Pelerito1,2
1Emergency Response and Biopreparedness Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal.
葡萄牙的Mpox疫情显示,在最初的浪潮之后,传播正在下降. 实验室监测和优化样本采集,特别是病变和直肠片,对于准确的诊断和有效的公共卫生反应至关重要.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 马波克斯在2022年在全球范围内重新出现,葡萄牙在2022年至2025年之间经历了三次爆发浪潮.
- 这种情况强调了需要强有力的实验室监测和公共卫生干预措施的需要.
研究的目的:
- 分析葡萄牙mopox疫情的流行病学趋势.
- 评估不同临床样本类型的诊断性能.
- 确定改善未来疫情准备的关键经验教训.
主要方法:
- 使用实时PCR分析了来自2802个疑似mopox病例的5610个临床样本.
- 评估病变,门,口和尿液样本的阳性率和病毒载荷 (Ct值).
主要成果:
- 在1202名患者中确认了Mpox,第一波占79.3%的病例.
- 伤口和直肠拭子显示出最高的诊断灵敏度 (95.1%和87.9%).
- 口腔囊片在病变阴性病例中有助于诊断;尿样显示出有限的效用.
结论:
- 持续的实验室监测和适应性的公共卫生策略对于控制mpox至关重要.
- 优化样本采集,优先考虑病变和直肠拭子,提高诊断准确性和早期检测.
- 持续监测,疫苗接种和风险沟通对于防止非特有地区的复苏至关重要.
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