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Updated: Sep 14, 2025

Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions
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Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions

Published on: October 21, 2016

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一个合作模型对对称的带与蛋白纤维结合

Matthew S Smith1,2, William F DeGrado1,3, Michael Grabe1,3

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, 1700 Fourth St., Byers Hall Suite 508D, San Francisco, California 94143, United States.

Biochemistry
|July 23, 2025
PubMed
概括

这项研究模拟了像阿尔茨海默氏症 (AD) 这样的神经退行性疾病中的联结物如何与tau蛋白聚合物结合. 了解合作性是解释诊断标记物具有约束力的数据的关键.

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The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
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