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托桑聚硫酸停止服用后,黄斑病的快速进展 酸停止服用
Melanie Tran1,2, Akshay Prashant Agnihotri1,2, Ines D Nagel1,2
1Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, California, United States of America, 92037.
Retinal cases & brief reports
|July 23, 2025
概括
即使在停止使用药物后,Pentosan聚硫酸 (PPS) 黄斑病也可能迅速进展. 这种获得性毒性疾病需要对患者进行仔细监测和支持性治疗.
科学领域:
- 眼科医生 眼科 眼科
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 松聚硫酸 (PPS) 用于间歇性囊炎.
- 眼睛的毒性,特别是PPS黄斑病,是已知的风险.
- 早期检测和监测对于管理与PPS相关的视网膜病变至关重要.
研究的目的:
- 为了记录多硫酸 (PPS) 黄斑病的病例.
- 突出PPS停止后几年的快速视网膜病变进展的潜力.
- 强调需要长期的患者监测.
主要方法:
- 一个75岁妇女的案例研究,视力逐渐变化.
- 综合眼科检查,包括多模式成像.
- 对已知风险等位基因进行基因检测.
主要成果:
- 患者在停止PPS治疗四年后出现了严重的视网膜变化和黄斑缩.
- 观察到视网膜色素表皮 (RPE) 异常和外视网膜损失.
- 基因测试显示了风险等位基因的同胞性.
结论:
- PPS巨病是一种获得的有毒性疾病,对生活质量有重大影响.
- 视网膜病变的进展可能发生在PPS停止后很长时间.
- 持续监测患者和支持性护理是必不可少的.
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