食品大营养素与肠道微生物组的相互作用影响:对宿主健康和风险的影响
Zhengwei Tan1, Chengcheng Yang1, Yan Zhao2
1Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Journal of agricultural and food chemistry
|July 23, 2025
概括
饮食中的宏观营养素被肠道微生物加工成影响宿主健康的代谢物. 了解这些相互作用有助于制定个性化的营养策略,以获得更好的健康结果.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 营养科学 营养科学
背景情况:
- 在小肠中未被吸收的宏观营养物质到达结肠,在那里肠道微生物将它们代谢成各种化合物.
- 这些微生物代谢物被吸收并影响宿主的生理功能.
- 特定的代谢物,如糖酸盐和醇衍生物,分别在葡萄糖平衡和神经健康方面发挥作用.
研究的目的:
- 探索肠道微生物群在代谢饮食中的宏观营养素中的作用.
- 研究微生物代谢物如何影响宿主生理和健康.
- 突出微生物群导向策略在精准营养中的潜力.
主要方法:
- 肠道微生物群对宏观营养素代谢的分析.
- 微生物代谢物的识别和表征.
- 研究代谢物吸收和生理效应.
- 探索宿主微生物群相互作用,包括lncRNA Snhg9在脂质代谢中的作用.
主要成果:
- 肠道微生物群将未消化的宏观营养素代谢成生物活性小分子.
- 酸盐是一种微生物代谢物,调节葡萄糖的恒常性.
- 来自蛋白质和酸盐的醇代谢物显示出在治疗神经病变疾病方面的潜力.
- 肠道微生物群和lncRNA Snhg9的相互作用影响脂质代谢.
结论:
- 饮食中的宏观营养素通过肠道微生物群代谢显著影响宿主健康.
- 微生物代谢产物为代谢和神经系统疾病提供治疗点.
- 准肠道微生物群为个性化营养和疾病管理提供了一个有希望的途径.
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