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通过索拉费尼布和ML385装载的CuFe2O4纳米酶增强铁灭症治疗

Yanzhao Yin¹, Junsheng Zhao¹, Mengxiao Liu¹

¹Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.

Colloids and surfaces. B, Biointerfaces

|July 23, 2025

概括

这项研究开发了铜酸盐纳米酶,通过增强活性氧物种 (ROS) 和抑制抗氧化剂来增强铁化癌症治疗. 巨细胞涂层的纳米酶通过光热疗法改善了瘤治疗的疗效.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

铁酶是一种有前途的癌症治疗方法,但其疗效受到芬顿反应和抗氧化剂 (如谷氨酸 (GSH) 和谷氨酸过氧化酶4 (GPX4)) 的限制.
克服这些局限性对于开发有效的基于铁灭的癌症治疗至关重要.

研究的目的:

合成和评估装有索拉芬尼和ML385的铜铁 (CuFe2O4) 纳米酶,用于增强癌症治疗.
研究ROS生成,抗氧化抑制和光热疗法 (PTT) 的协同效应,以改善铁灭诱导.

主要方法:

铜铁 (CuFe2O4) 纳米酶被合成并加载索拉芬尼和ML385.5.
纳米酶被巨细胞膜覆盖,以逃避网状内皮系统 (RES).
评估了纳米酶的催化活性,ROS生成,抗氧化抑制和PTT效应.

主要成果:

CuFe2O4纳米酶表现出卓越的芬顿反应催化活性,这是由于共存的铁和铜离子.
索拉费尼布和ML385分别有效抑制了GSH合成和NRF2表达,从而抑制了抗氧化防御.
巨细胞涂层的纳米酶表现出增强的瘤积累和强大的治疗疗效通过联合ferroptosis和PTT.

结论:

开发的纳米平台有效地消耗GSH,产生高水平的ROS,并提供出色的光热疗法 (PTT) 效果.
这种多功能纳米平台显示出通过增强铁灭症来改善癌症治疗结果的巨大潜力.
巨细胞膜涂层提高了纳米酶的体内性能,突出了其在药物输送系统中的实用性.

关键词:

铜铁酸盐铜铁酸盐的使用情况铁性化 (ferroptosis) 是一种消耗GSH的GSH可以使用.纳米酶是一种纳米酶.有反应性氧物种的反应性氧物种.

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