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相关概念视频

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

332
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
332
Elastic Strain Energy for Shearing Stresses01:20

Elastic Strain Energy for Shearing Stresses

292
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
292
Dynamic Modulus of Elasticity of Concrete01:16

Dynamic Modulus of Elasticity of Concrete

549
The dynamic modulus of elasticity assesses how a concrete structure deforms under impact or dynamic loads. It is typically higher than the static modulus of elasticity, measured under slow, steady loading conditions.
The sonic test is a common method to determine the dynamic modulus. In this test, a concrete beam, sized either 6 x 6 x 30 inches or 4 x 4 x 20 inches, is clamped at its center. Vibrations are initiated at one end of the beam by an electromagnetic exciter unit powered by...
549
Generalized Hooke's Law01:22

Generalized Hooke's Law

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The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
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Viscosity of Fluid01:19

Viscosity of Fluid

697
Viscosity measures the resistance a fluid offers to flow and deformation. It results from internal friction between layers of fluid moving relative to one another. Dynamic viscosity, denoted by the Greek letter mu (μ), quantifies the force needed to move one fluid layer over another. For Newtonian fluids like water and air, the relationship between the shearing stress and the rate of shearing strain is linear, meaning their viscosity remains constant regardless of the applied stress.
697
Strain and Elastic Modulus01:15

Strain and Elastic Modulus

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The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
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相关实验视频

Updated: Sep 14, 2025

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
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Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

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一个适合的模型用于计算细胞粘弹性参数.

Guanlin Zhou1, Chao Wang1, Chengwei Wu1

  • 1State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment, School of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian 116024, China.

Journal of biomechanics
|July 23, 2025
PubMed
概括

这项研究引入了一种新模型,使用原子力显微镜 (AFM) 准确测量细胞粘弹性质. 改进的方法纠正了标准模型中的错误,使细胞刚度和粘度能够精确确定.

科学领域:

  • 生物物理学的生物物理.
  • 细胞力学 细胞力学
  • 生物材料科学 生物材料科学

背景情况:

  • 细胞粘弹性属性是细胞行为和疾病状态的关键指标.
  • 原子力显微镜 (AFM) 缩影是测量这些特性的一种常见方法.
  • 现有的模型,比如赫兹模型,由于不符合缩场景和忽视有限细胞扩散而存在局限性.

研究的目的:

  • 开发一个纠正的AFM缩模型,解决现有方法的局限性.
  • 从细胞内数据中准确地提取粘弹性参数 (弹性模量,表面粘度).
  • 为了克服由赫兹模型假设和细胞的有限扩散面积产生的错误.

主要方法:

  • 基于有限元数据的纠正模型的开发.
  • 通过计算模拟对模型的验证.
  • 实验验证使用AFM对细胞的缩实验.

主要成果:

  • 提出的模型有效地消除了与赫兹模型假设相关的错误.
  • 它解释了细胞的有限扩散区域,这是一个经常被忽视的因素.
  • 这样可以准确地提取关键的粘弹性参数,如弹性模量和表面粘度.
关键词:
航空飞行管理 (AFM)细胞机械生物学 细胞机械生物学赫兹模型是赫兹模型.粘性弹性 粘性弹性

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结论:

  • 新的修正模型为量化细胞粘性弹性提供了更准确的方法.
  • 这一进步对了解健康和疾病中的细胞力学有重大影响.
  • 这些发现允许使用AFM对细胞进行更可靠的生物力学表征.