认知和行为路径从产前可卡因暴露到新兴成年期经常使用大麻的认知和行为路径
Sonia Minnes1, Meeyoung O Min2, Sun Kyung Kim1
1Jack, Joseph and Morton Mandel School of Applied Social Sciences, 11235 Bellflower Road, Cleveland, OH, United States.
Drug and alcohol dependence
|July 23, 2025
概括
产前可卡因暴露 (PCE) 与新兴成年人经常使用大麻有关. 早期的执行功能缺陷调解了这种关系,这表明有针对性的干预措施可以帮助预防物质使用.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 产前可卡因暴露 (PCE) 与长期的神经发育和行为挑战有关.
- 了解从PCE到后期物质使用的途径对于有效的预防策略至关重要.
研究的目的:
- 研究执行功能,外部化行为和感知推理对PCE和21岁定期使用大麻之间的关联的间接影响.
- 确定PCE与青少年/成年人物质使用之间的关系中的潜在调解因素.
主要方法:
- 一项从出生开始评估的310名参与者 (154名PCE,156名非PCE) 的纵向研究.
- 在12岁时评估执行功能 (全球执行组合),感知推理 (PRIQ),外部化行为 (EXT),并在15岁时使用物质.
- 结构方程建模用于分析认知和行为因素在将PCE与21岁时的普通大麻使用联系起来的调解作用.
主要成果:
- 患有PCE的个体在21岁时报告经常使用大麻的比率更高,相比于未暴露的个体.
- 12岁时全球执行功能较差与15岁时增加的物质使用有关,这反过来又预测了21岁时的定期大麻使用.
- 发现PCE对经常使用大麻的间接影响,通过早期执行功能和青少年物质使用来调解.
结论:
- 在产前接触可卡因后,执行功能的早期缺陷可以预测以后的定期大麻使用.
- 针对早期儿童的认知和行为模式的干预措施可能有助于减轻PCE患者在新兴成年期使用物质的风险.
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