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在姊妹研究中,空气中的甲酸盐暴露和高血压

Jing Xu¹, Dale P Sandler²

¹Beijing Center for Disease Prevention and Control, Beijing 100013, China.

Journal of hazardous materials

|July 23, 2025

概括

空气中的甲酸盐暴露,包括DEHP,DBP和DMP,与女性高血压风险增加有关. 这些关联在非白人种族/族群中更为明显.

科学领域:

环境健康环境健康
流行病学流行病学
毒理学毒理学毒理学

背景情况:

高血压是一个全球性的健康问题,影响了全球近10亿人.
空气中甲酸盐暴露与高血压之间的关系尚不清楚.
酸盐是各种消费品中常见的内分泌干扰化学物质.

研究的目的:

调查空气中甲酸盐暴露与高血压患病率之间的关联.
为了检查多个空气中甲酸盐对高血压风险的联合影响.
探索不同种族/种族群体之间这些协会的潜在差异.

主要方法:

从姐妹研究中对47465名女性进行横截面分析.
使用美国环保署国家空气毒性评估数据库估计的空气中甲酸盐暴露 (DEHP,DBP,DMP).
通过血压值或药物使用来定义高血压;使用多变量逻辑双项回归和g计算进行分析.

主要成果:

接触比斯 (2-乙烯基) 甲酸盐 (DEHP),迪布蒂尔甲酸盐 (DBP) 和二甲基甲酸盐 (DMP) 与高血压风险增加有关.
对DEHP和DMP的关联分别在非西班牙裔白人和其他种族/族群的女性中更强.
甲酸盐混合物的四分之一增加与高血压患病率的2%上升有关.

结论:

空气中的甲酸盐暴露与高血压患病率的增加有关.
空气中的甲酸盐对高血压风险的影响可能因种族/族群而异.
这些发现强调了在高血压预防策略中需要考虑环境甲酸盐的暴露.

关键词:

血压血压血压血压在高血压的高血压.混合物混合物混合物甲酸的含量甲酸的含量

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