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Updated: Sep 14, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Published on: January 26, 2018

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表观基因组分析识别了H3K27me3 在人类皮质发生过程中对细胞外矩阵组成的调节

Nora Ditzer1, Ezgi Senoglu1, Annika Kolodziejczyk1

  • 1Center for Regenerative Therapies TU Dresden, TUD Dresden University of Technology, 01307 Dresden, Germany.

Neuron
|July 23, 2025
PubMed
概括

这项研究揭示了表观遗传标记,特别是Polycomb repressive complex 2 (PRC2) 的H3K27me3,是如何影响人类大脑发育的. 抑制PRC2改变的神经原生细胞 (NPC) 分化和细胞外基因表达.

关键词:
多镇压复合体 2 2大脑发育大脑发育的大脑发育细胞外矩阵是细胞外矩阵.基因表达的基因表达方式基因组胺甲基化 基因组胺甲基化人类皮层有机体人类胎儿皮层神经干细胞的神经干细胞神经发生神经的产生.一个单细胞的单细胞.

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