双重战斗:比较强迫症的六年过程与并发性饮食障碍和没有并发性饮食障碍
Boris van Passel1, Unna N Danner2, Merijn Eikelenboom3
1Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care, Pro Persona, Nijmegen, the Netherlands; Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands.
Journal of affective disorders
|July 23, 2025
概括
患有强迫症 (OCD) 和饮食障碍 (ED) 的个人经历了长期的强迫症症状严重程度的降低,与没有ED的人相似. 然而,组合组的初始临床负担较高,表明需要量身定制的治疗.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 强迫症 (OCD) 经常与饮食障碍 (ED) 一起发生.
- 这种并发性疾病与症状严重程度增加,抑郁症和治疗结果较差有关.
- 在患有并发性ED的患者中,强迫症的长期临床过程尚不清楚.
研究的目的:
- 为了研究强迫症症状严重程度的6年临床过程,在有和没有ED的终身病史的患者中.
- 为了比较这两个群体在六年内强迫症症状严重程度的轨迹.
主要方法:
- 一组382名DSM-IV强迫症诊断的参与者被分为强迫症+ED (n=46) 和强迫症-ED (n=336) 组.
- 终身ED诊断包括神经性厌食症和过度饮食障碍.
- 强迫症和ED诊断,症状严重程度和临床变量在基线和六年内使用线性混合效应模型进行了评估.
主要成果:
- 患有强迫症+ED的参与者表现出更高的强迫症,抑郁症和焦虑症症状的基线水平,以及更多的PTSD并发症.
- 尽管有初始差异,但两组的强迫症症状严重程度的6年轨迹相似.
- 在六年研究期间,在症状减轻方面没有发现显著的群体间差异.
结论:
- 并发性ED并没有显著改变强迫症症状严重程度的长期过程.
- 患有强迫症+ED的患者在基线时临床负担较大.
- 这些发现表明,对于伴随性强迫症和ED患者来说,可能需要更密集或更长时间的治疗,尽管OCD + ED组的样本规模很小是一个局限性.
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