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Updated: Sep 14, 2025

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PERK和IRE1α通过阻断多个膀体的溶酶体降解来促进外体分泌

Shixin Zhou1, Zihan Zhou1, Si Chen1

  • 1State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, P.R. China.

The Journal of biological chemistry
|July 23, 2025
PubMed
概括

细胞内膜网膜 (ER) 的压力通过未折叠的蛋白质反应 (UPR) 触发了外体分泌. 这一过程涉及PERK和IRE1α通路抑制 lysosomes,促进细胞通信的外体释放.

关键词:
这就是IRE1α.一个叫Perk的Perk.细胞外囊泡细胞外囊泡lysosome 溶解酶体是如何形成的不折叠的蛋白质反应反应

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