杏仁体中的神经功能障碍与伴随性结肠炎的焦虑类行为有关
Kohei Takahashi1, Kazuhiro Kurokawa1, Kazuya Miyagawa1
1Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi 324-8501, Japan.
Neuroscience letters
|July 23, 2025
概括
性结肠炎 (UC) 模型小鼠表现出焦虑行为和杏仁体中改变的c-Fos表达,这表明神经元功能障碍有助于UC相关的焦虑.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,与焦虑和抑郁症等精神疾病有关.
- 德克斯硫酸 (DSS) 诱导的小鼠模型模仿UC症状并表现出类似焦虑的行为,但潜在的神经机制尚不清楚.
研究的目的:
- 为了研究神经活动的变化,特别是c-Fos表达,以应对DSS诱导的UC小鼠模型中的急性压力.
- 探索杏仁体在UC相关焦虑中的作用.
主要方法:
- 用DSS治疗小鼠,诱导大肠炎类症状和焦虑行为.
- 在行为测试和应激暴露后,在大脑区域,特别是杏仁体,量化了c-Fos表达,GluN1酸化,ERK1/2酸化和synaptophysin水平.
主要成果:
- 用DSS治疗的小鼠表现出类似焦虑的行为,并在前额皮层和杏仁体中改变了c-Fos表达.
- DSS治疗导致杏仁体中c-Fos表达和GluN1酸化降低,与焦虑行为相关.
- 用DSS治疗的小鼠在杏仁体中没有显示压力诱导的ERK1/2酸化,并且减少了synaptophysin表达.
结论:
- 在接受DSS治疗的小鼠中,UC类症状与焦虑类行为有关.
- 杏仁体中的神经功能障碍,由改变的基因表达和酸化模式表明,可能是性结肠炎相关的焦虑的基础.
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