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间歇性禁食通过调节肠道微生物群来改善耐性高血压
Fengxiang Yun1, Xuejie Han1, Zhiqi Wang1
1Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Pharmacological research
|July 23, 2025
概括
间歇性禁食 (IF) 和Akkermansia muciniphila补充剂在耐性高血压中有效降低血压. 这种方法改善了肠道微生物群,减少了LPS和TMAO等有害毒素,并增强了有益的SCFA.
科学领域:
- 心血管研究研究心血管研究
- 微生物组科学 微生物组科学
- 代谢健康 代谢健康
背景情况:
- 抗性高血压 (RH) 尽管采用标准治疗方法,但仍具有显著的心血管风险.
- 间歇性禁食 (IF) 的作用及其在RH中的机制尚不清楚.
研究的目的:
- 研究IF对RH患者和自发高血压大鼠 (SHRs) 的血压和肠道微生物群的影响.
- 探索特定肠道细菌的潜力,Akkermansia muciniphila和Adlercreutzia equolifaciens,作为RH的治疗剂.
主要方法:
- 对RH患者和SHR患者进行了为期2周的间歇性禁食 (16小时禁食/8小时饮食) 方案.
- 便微生物群移植 (FMT) 用于评估肠道微生物群在高血压中的因果作用.
- 用A. muciniphila和A. equolifaciens补充剂在SHRs和A. muciniphila在RH患者中进行了测试.
主要成果:
- 在RH患者和SHR患者中,IF显著降低了血压.
- IF改变了肠道微生物群的组成,增加了A. muciniphila和A. equolifaciens,并减少了LPS和TMAO,同时增加了SCFA.
- 来自耐药SHRs的FMT传播了高血压和药物反应受损.
- 补充A. muciniphila和A. equolifaciens降低了SHR和RH患者的血压,使代谢标志物正常化.
结论:
- 间歇性禁食和Akkermansia muciniphila补充剂显示出作为管理耐药高血压的非药物战略的希望.
- 肠道微生物群调节代表了对诸如RH等心血管疾病的可行的治疗途径.
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