微/纳米塑料驱动的心血管衰老和传统中医的多目标干预
Yuan Liu1, Yuetong Li2, Yue Yin2
1School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046, China; Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710000, China.
Ageing research reviews
|July 23, 2025
概括
微/纳米塑料 (MNP) 通过破坏线粒体并引发炎症来加速心血管衰老. 传统中医 (TCM) 提供了一种整体方法来抵消这些塑料污染的影响.
科学领域:
- 环境毒理学环境毒理学
- 经年保护 (Geroprotection) 是一种老年保护.
- 心血管科学 心血管科学
背景情况:
- 微/纳米塑料 (MNP) 是普遍存在的污染物,在心血管组织中积累.
- 通过复杂的病理生理过程,MNP积累导致心血管过早衰老.
研究的目的:
- 综合证据,将MNP暴露与心血管衰老联系起来.
- 确定环境现象型衰老作为一个关键机制.
- 探索传统中医 (TCM) 作为对策.
主要方法:
- 对MNP毒性和心血管衰老的现有科学文献的审查.
- 分析受MNP影响的分子通路,包括线粒体损伤,表观遗传变化和炎症.
- 对MNP诱导的心血管损伤的TCM治疗策略的评估.
主要成果:
- 许多MNP诱导线粒体损伤 (晶状体破坏,mtDNA泄漏激活cGAS-STING).
- MNPs导致表观遗传重编程 (METTL3介导的m6A高甲基化,SIRT1/3抑制) 和端粒磨损.
- 许多MNP促进NLRP3炎症酶依赖性炎症,有助于心血管衰老.
结论:
- 传统医疗的多化合物疗法有效地准关键途径 (氧化应激,纤维化,细胞死亡),以恢复心血管平衡.
- 传统医疗医学提出了一种整体的,改变范式的干预措施,以对抗塑料污染引起的心血管衰老.
- 这项研究提供了用于减轻公共卫生危机的实际策略.
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