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植物多糖通过多组织保护和多目标机制减轻电离辐射损伤:一项审查
Zhu Ruiqing1, Jiang Yiping1, Li Kun1
1Department of Pharmacognosy, School of Pharmacy, Naval Medical University, Shanghai, China.
International journal of biological macromolecules
|July 23, 2025
概括
植物多糖类通过减少氧化应激和炎症,对电离辐射 (IR) 提供自然保护. 它们在功能性食品中的使用是管理辐射诱导的生物风险的一个有希望的策略.
科学领域:
- 生物化学 生化学
- 放射学 放射学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 辐射技术的越来越多的使用导致人类对电离辐射 (IR) 的暴露越来越高,导致显著的生物风险.
- 植物多糖是生物相容,安全和生物活性的大分子,具有作为辐射保护剂的潜力.
- 现有证据表明,植物多糖具有针对IR的多目标保护作用.
研究的目的:
- 审查2014年至今关于植物多糖的辐射保护功效的研究进展.
- 分析植物多糖在放射敏感系统的保护机制,如造血,胃肠道和生殖组织.
- 检查结构-活动关系,并确定临床翻译的挑战.
主要方法:
- 2014年至今发表的研究文献综述.
- 保护机制的分析,包括氧化应激减弱,免疫恒常度调节和亡调节.
- 案例研究研究了代表性多糖体的结构-活性关系.
主要成果:
- 植物多糖体在造血,胃肠道和生殖系统中表现出辐射保护作用.
- 关键的机制包括减轻氧化应激,平衡免疫反应和调节细胞死亡途径.
- 多糖的结构多样性影响其有效性,但也给标准化带来了挑战.
结论:
- 植物多糖体具有显著的辐射保护潜力,特别是通过向氧化应激和亡的机制.
- 结构异质性对制药开发和临床应用提出了挑战.
- 使用植物多糖开发功能性食品是克服这些障碍并为未来药物开发提供信息的可行策略.
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