在血液淋巴瘤恶性瘤中,基于细胞因子的免疫疗法.
Mário Sousa-Pimenta1, Nuno R Dos Santos2
1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal; Department of Hematology and Bone Marrow Transplantation, Portuguese Institute of Oncology of Porto (IPO Porto), Porto, Portugal.
International review of cell and molecular biology
|July 23, 2025
概括
生物工程细胞因子正在重新评估用于癌症治疗,在与其他疗法结合时,为血液性恶性瘤提供了改进的治疗方法. 这些进展增强了免疫反应和患者的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 细胞因子对于免疫调节至关重要,弥合了先天性和适应性免疫力.
- 早期的细胞因子疗法面临着挑战,原因是药理动力学不佳和新治疗方法的竞争.
- 最近的生物工程已经改善了细胞因子的半衰期和减少了副作用,促使重新评估.
研究的目的:
- 审查最近基于细胞因子治疗血液性恶性瘤的进展.
- 探索细胞因子作为单一治疗和组合治疗的使用.
- 突出细胞因子在增强细胞疗法和免疫复原中的作用.
主要方法:
- 对基于细胞因子的癌症疗法的当前文献的综述.
- 对具有改善药理动力学特征的生物工程细胞因子进行分析.
- 检查涉及细胞因子,化疗和细胞疗法的组合策略.
主要成果:
- 生物工程类型的细胞因子显示出改善治疗潜力的前景.
- 细胞因子增强单克隆抗体,免疫检查点抑制剂和癌症疫苗的疗效.
- 细胞因子支持细胞疗法的ex vivo扩张和in vivo功能,并帮助移植后的免疫复原.
结论:
- 基于细胞因子的疗法正在重新振兴,特别是在血液性恶性瘤中.
- 涉及细胞因子的组合策略提供了增强的治疗选择.
- 在瘤学中,细胞因子在改善免疫功能和患者结果方面发挥着至关重要的作用.
相关概念视频
Tumor Immunotherapy
662
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
662
Cytotoxic T Cells-mediated Immune Response
2.1K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
2.1K
Regulation of Hematopoietic Stem Cells
3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K


