可纳与天然和制药来源的化合物结合使用:对它们对Candida auris的抗菌活性进行研究
Iñigo de-la-Fuente1, Andrea Guridi1, Guillermo Quindós2
1Department of Immunology, Microbiology and Parasitology (UFI11/25), Faculty of Medicine and Nursing, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain.
Revista iberoamericana de micologia
|July 23, 2025
概括
结合马格诺洛尔,咖啡酸乙烯或奎尔酸的可纳在治疗Candida auris感染方面表现有前途. 这些组合表明了添加剂或协同的抗真菌作用,降低了可纳耐药性.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- кандидоз是一种常见的真菌感染.
- 黄是一种新兴的病原体,会引起严重的,耐药的感染.
- 将可纳与其他药物结合使用可以克服抗真菌耐药性.
研究的目的:
- 评估与天然化合物和药物相结合的可纳的抗真菌作用,对 auris.
- 为了确定fluconazole与各种药物之间的添加剂或协同作用.
主要方法:
- 测试了与14种药物 (7种天然化合物,7种药物) 结合的可纳,对21种Candida auris分离物进行了测试.
- 确定最小抑制度 (MIC) 来评估抗真菌活性和相互作用.
主要成果:
- 弗卢科纳与马格诺洛尔,咖啡酸乙烯或奎尔酸盐分别在38%,9.5%和2%的分离物中表现出添加效应.
- 在19%的隔离物中观察到与奎尔酸的协同效应.
- 组合剂显著降低了可纳的MIC,特别是与马格诺洛尔和奎尔酸盐.
结论:
- 马格诺洛尔,咖啡酸乙烯和奎尔酸显示出增强弗卢科纳对抗白菌的功效的潜力.
- 这些组合可能为管理难以治疗的角膜炎症提供新的治疗策略.
- 需要进一步的体内研究来确认临床适用性.
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