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Updated: Sep 14, 2025

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Development of Compendium for Esophageal Squamous Cell Carcinoma
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AP-1因子JUNB与患有食道腺癌的患者的生存率差相关
Nikolai Schleussner1, Karl Knipper2, Ella Leugner3
1Department of General, Visceral, Thorax and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. nikolai.schleussner@uk-koeln.de.
Scientific reports
|July 23, 2025
概括
在食道癌患者中,高JUNB表达与生存率降低相关. 同时表达cJUN和JUNB进一步恶化了结果,表明JUN因素是患者分层的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 与非转化细胞相比,恶性细胞表现出不受调节的转录网络.
- 激活蛋白-1 (AP-1) 转录因子复合体,包括cJUN和JUNB,与癌症进展和瘤促进有关.
- 尽管采用多式疗法,食道癌仍然是一个重大的生存挑战,这凸显了改善患者分层的必要性.
研究的目的:
- 研究食道癌中cJUN和JUNB的表达.
- 评估cJUN和JUNB表达和患者生存结果之间的相关性.
- 确定JUN因子作为食道癌患者分层的生物标志物的潜力.
主要方法:
- 进行了免疫组织化学染色,以评估cJUN和JUNB表达水平.
- 表达数据与735名食道癌患者队列中的临床结果相关.
- 进行多变量和子组分析以确定独立的预后因素.
主要成果:
- 高JUNB表达与食道癌患者的整体存活率 (OS) 降低显著相关.
- 高JUNB表达成为降低患者存活时间的独立风险因素.
- 同时表达cJUN和JUNB的瘤与单独表达或不表达这些因素的瘤相比,显示了较差的生存状况.
- 在新辅助治疗子组中,在高JUNB表达的患者中观察到显著减少的OS.
结论:
- JUNB表达作为食道癌的潜在预后生物标志物.
- 联合表达cJUN和JUNB表明预后较差.
- JUN因子可能有助于分层患者,特别是那些接受新辅助疗法的患者.
- 准JUN途径可能为食道癌提供补充治疗策略.
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