双金属银二氧化纳米颗粒的绿色生物合成,使用Pluchea indica及其抗癌,抗微生物和抗氧化活性
Samy Selim1, Bahaa M Badr2,3, Mohamed H Moustafa4
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia.
Scientific reports
|July 23, 2025
概括
这项研究使用Pluchea indica树叶提取物生物合成了二氧化银-二氧化双金属纳米粒子 (Ag-TiO2 BNPs). 环保纳米颗粒显示出显著的抗癌,抗菌和抗氧化活性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物技术是生物技术.
背景情况:
- 双金属纳米颗粒的传统合成通常涉及昂贵且对环境有害的化学或物理方法.
- 自然植物提取物为纳米粒子生物合成提供了可持续和经济的替代方案.
- Pluchea indica 叶子提取物具有作为纳米粒子合成的绿色减少和封闭剂的潜力.
研究的目的:
- 使用Pluchea indica树叶提取物生物合成二氧化银-双金属纳米颗粒 (Ag-TiO2 BNPs).
- 使用各种分析技术来描述合成的Ag-TiO2 BNPs.
- 评估生物合成的Ag-TiO2 BNPs的抗癌,抗菌和抗氧化特性.
主要方法:
- 使用Pluchea indica树叶提取物生物合成Ag-TiO2 BNPs.
- 通过紫外线光谱,FTIR,传输电子显微镜 (TEM),X射线衍射 (XRD) 和动态光散射 (DLS) 进行表征.
- 在体外评估抗癌活性对MCF-7和Wi-38细胞系,抗菌活性对病原菌株和抗氧化活性.
主要成果:
- 紫外线-Vis光谱学证实了成功的合成,吸收峰值在350nm.
- TEM分析表明Ag-TiO2 BNPs的平均直径在10至60nm之间.
- 生物合成的Ag-TiO2 BNPs表现出显著的抗癌活性 (IC50 = 33.5μg/mL对MCF-7),抗菌特性 (MIC = 31.2562.5μg/mL) 和抗氧化活性 (IC50 = 225μg/mL).
结论:
- 普鲁希亚印加叶提取物对Ag-TiO2 BNPs的绿色合成有效.
- 生物合成的Ag-TiO2 BNPs具有显著的抗癌,抗菌和抗氧化生物活性.
- 这些发现突显了植物衍生纳米颗粒在生物医学应用中的潜力.
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