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通过LYCHOS-mTORC1通路对胆固醇感应的结构性见解

Shang Yu1, Jin-Hui Ding2, Jia-le Wang2,3

  • 1Department of Biophysics, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Nature communications
|July 23, 2025
PubMed
概括

溶酶体胆固醇传感器LYCHOS调节mTORC1的信号传递. 结构研究揭示了胆固醇结合如何改变LYCHOS形状,影响GATOR1相互作用和mTORC1通路调节.

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