分析影响口服药物处理困难的因素,使用基于电子药物笔记本的个人健康记录
Yuri Shimizu1, Masami Tsuchiya1, Masaki Asano1
1Division of Drug Informatics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Scientific reports
|July 23, 2025
概括
许多患者难以处理小口服药物,影响其坚持. 这项研究发现,药物的尺寸和手的灵敏度显著有助于处理困难,为以患者为中心的药物设计提供了信息.
科学领域:
- 制药科学 制药科学
- 患者坚持的研究研究.
- 老年医学 老年医学
背景情况:
- 口服药物,包括药片和囊,是常见的,但对一些患者来说,它们的处理是具有挑战性的.
- 难以处理药物可能会导致药物遵守率降低,并对健康结果产生负面影响.
- 了解有助于处理困难的因素对于改善药物可用性至关重要.
研究的目的:
- 确定与处理口服药物的感知困难相关的因素.
- 分析药物特征,患者背景和处理挑战之间的关系.
- 在配方设计和处方方面提供以患者为中心的方法.
主要方法:
- 利用harmo®的数据,这是一个全国性的电子药物笔记本系统.
- 向成年口服药物使用者分发问卷,将答案与个人健康记录联系起来.
- 采用ROC分析来确定尺寸值和二项逻辑回归来分析影响因素.
主要成果:
- 在1230名受访者中,有24%的人报告说,他们难以处理小片或囊.
- 总直径≤13.3毫米与处理问题密切相关 (ROC-AUC=0.834).
- 与困难显著相关的因素包括手的灵巧度下降,药物大小小,高血压和骨质疏松症.
结论:
- 物理配方特性和个体患者因素都会影响药物处理的可用性.
- 确定特定的药物大小值可以帮助预测处理困难.
- 这些发现支持量身定制口服配方设计和处方实践,以提高患者遵守和安全.
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