一个微生物模式的肠道感知调节食
Winston W Liu1,2,3,4, Naama Reicher1,3, Emily Alway1,2,3
1Laboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Nature
|July 23, 2025
概括
科学家发现了一种新的肠-大脑感觉, 这种感觉使用鞭毛蛋白,一种微生物分子,通过Toll-like受体5 (TLR5) 向大脑发出信号并调节食行为.
科学领域:
- 神经科学
- 微生物学
- 胃肠病学
背景情况:
- 主体需要感知和响应寄居微生物的机制.
- 肠道与大脑之间的沟通调节了宿主行为, 包括食选择.
- 对于肠道微生物刺激的实时感官机制以前是未知的.
研究的目的:
- 发现一种能使宿主对肠道微生物刺激作出反应的感官机制.
- 确定肠道微生物感应所涉及的分子通路.
- 描述这种感官在调节宿主行为中的作用.
主要方法:
- 研究了鞭毛素对小鼠大肠神经动物细胞的影响.
- 使用托尔类受体5 (TLR5) 淘汰模型.
- 检查的YY (PYY) 释放和节神经元激活.
- 评估养行为和体重增加作为对鞭毛蛋白的反应.
主要成果:
- 在结肠神经细胞中刺激TLR5,导致PYY释放.
- 这种信号通路可以调节食行为,减少食物摄入量.
- 在神经动物细胞中缺乏TLR5的小鼠的食物摄入量增加和体重增加.
- 弗拉格林诱导的食减少与免疫反应或微生物群的存在无关.
结论:
- 一个新的肠-大脑感觉通路, 神经生物感觉, 已被确定.
- 这种感觉使宿主能够调整行为以应对像鞭毛状的微生物分子模式.
- 神经生物感官通过肠-大脑神经电路运行, 涉及神经足细胞和迷走神经元.
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