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系统性细胞因子驱动在细菌和病毒感染中保存的严重程度相关的髓质反应

Kimberly Kajihara1, Donghong Yan2, Gretchen L Seim1

  • 1Department of Infectious Diseases, Genentech, South San Francisco, CA, USA.

Communications biology
|July 23, 2025
PubMed
概括

严重的感染引发紧急骨髓形成 (EM),其特征是IL1R2+骨髓细胞增加. 颗粒细胞殖民地刺激因子 (G-CSF) 和干白素-6 (IL-6) 协同驱动这种反应,将髓状细胞失调与器官损伤联系起来.

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