血清葡萄糖比率与有毒脑病症重症患者的死亡率之间的U形关系
Lei Sun1, Feng Shao1, Ting Liu1
1Department of Critical Care Medicine, Jingzhou Hospital Affiliated to Yangtze University, No.26 Chuyuan Avenue, Jingzhou District, Jingzhou, 434020, Hubei Province, China.
Scientific reports
|July 23, 2025
概括
葡萄糖-比 (GPR) 显示了严重病情的有毒脑病变患者的死亡率与U形关联. 低GPR水平和高GPR水平都与全因死亡率 (ACM) 的增加有关.
科学领域:
- 关键护理医学 关键护理医学
- 临床生物化学 临床生物化学
- 毒理学 毒理学 毒理学
背景情况:
- 血清葡萄糖比率 (GPR) 与重症有毒脑病变 (TE) 患者的死亡率之间的关系尚不清楚.
- 了解GPR的影响对于管理TE和改善患者的治疗结果至关重要.
研究的目的:
- 调查血清葡萄糖比率 (GPR) 波动与有毒脑病变 (TE) 严重患者的死亡率之间的关联.
主要方法:
- 使用MIMIC-IV数据库的数据分析了需要ICU护理的3,462名TE患者的队列.
- 患者被分为三个GPR三层,并使用考克斯回归模型来评估28天和90天全因死亡率 (ACM).
- 限制立方线被用来探索GPR和死亡率之间的潜在非线性关系.
主要成果:
- 整体队列的28天和90天ACM率分别为21.9%和31.2%.
- 多变量分析显示了GPR水平和ACM之间的U形关联,最低 (T1) 和最高 (T3) 的GPR三位体与中位体 (T2) 相比,与死亡率的增加有关.
- 具体来说,28天ACM的调整后危险比为T1的1.20和T3的1.22;90天ACM的调整后危险比为T1的1.19和T3的1.20.
结论:
- 血清葡萄糖比率 (GPR) 和所有原因死亡率 (ACM) 在重症毒性脑病变 (TE) 患者之间存在显著的U形关系.
- 异常低和高的GPR水平都与短期和中期死亡率的增加独立相关.
- 临床监测和管理策略应考虑GPR水平,以潜在地减轻TE患者的死亡风险.
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