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Updated: May 6, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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Published on: June 12, 2021

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早期的氨酸可用性减弱了T细胞耗尽的作用

Piyush Sharma1, Ao Guo2,3, Suresh Poudel2

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. piyush.sharma@stjude.org.

Nature immunology
|July 23, 2025
PubMed
概括

在T细胞受体 (TCR) 激活过程中早期限制 metionin 促进T细胞疲劳. 氨酸的可用性调节KCa3.1甲基化,影响信号传递和NFAT1激活,从而影响疾病模型中的T细胞功能.

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