在老年人中推进多发性硬化症管理.
Anneke van der Walt1, Eva M M Strijbis2, Francesca Bridge3
1School for Translational Medicine, Department of Neuroscience, Faculty of Medicine, Monash University, Melbourne, VIC, Australia. anneke.vanderwalt@monash.edu.
Nature reviews. Neurology
|July 23, 2025
概括
随着患有多发性硬化症 (MS) 的人的寿命越长,管理这种疾病变得越来越复杂. 这份共识声明解决了MS老龄化的独特挑战,并为未来的研究和护理提供了建议.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 诊断通常发生在早期到中年成年期.
- 医疗保健的进步使得多发性硬化症患者的寿命更长,目前大约50%的患者年龄在50岁或以上.
- 随着年龄的增长,由于生理变化,免疫和并发症,MS诊断,治疗和管理变得更加复杂.
研究的目的:
- 审查当前对患有多发性硬化症的衰老的理解.
- 确定老年人多发性硬化症的诊断,治疗和管理方面的知识差距.
- 为未来的研究和临床实践提供有关衰老和MS的建议.
主要方法:
- 基于国际临床试验咨询委员会 (IACCT) 在MS研讨会上的共识声明.
- 审查当前的文献和关于衰老和多发性硬化症的研究现状.
- 确定未得到满足的需求,并提出建议.
主要成果:
- 晚期发作的MS诊断需要与与年龄相关的疾病区分开来.
- 与年龄相关的生理变化可能会影响疾病监测 (MRI,残疾,认知).
- 对于患有多发性硬化症的老年人来说,治疗决策是具有挑战性的,因为高效疗法的风险增加和益处减少.
结论:
- 衰老显著影响了多发性硬化症管理的复杂性.
- 需要更多的证据来指导MS老年人的治疗和护理.
- 提供了推,以推进研究和解决与MS老龄化的未满足需求.
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