具有pH-响应性半孔二氧化纳米粒子增强复合树脂,具有重矿化能力
Yongcheng Ge1, Ting Zhao2, Yuguang Liu3
1Department of Geriatric Stomatology, Hospital of Stomatology, Jilin University, Changchun, 130026, China.
BMC oral health
|July 23, 2025
概括
这项研究开发了含有化酸盐 (Pchi) /无形酸盐 (ACP) 和半孔二氧化纳米颗粒 (MSN) 的先进复合树脂,用于增强牙修复. 组A显示出优越的机械强度,而组D在牙重矿化方面表现出色.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 纳米技术纳米技术
背景情况:
- 复合树脂对于牙科修复至关重要,但往往缺乏寿命.
- 提高机械性能和促进重矿化是改善恢复耐久性的关键.
- 响应pH的材料具有控制离子释放和组织再生的潜力.
研究的目的:
- 开发和评估一种新的pH响应复合树脂.
- 为了增强功能,将化奇托 (Pchi) /无形酸 (ACP) 和氨基功能化介质纳米粒子 (MSN) 纳入.
- 评估开发的复合树脂的机械性能,重矿化潜力和生物相容性.
主要方法:
- 合成了MSN和Pchi/ACP,形成了Pchi/ACP@A-MSN复合体.
- 制定了五个复合树脂组,具有不同的填充成分 (A-MSNs,Pchi/ACP,Pchi/ACP@A-MSNs).
- 测量了双键转换,机械性质 (柔性强度,模量,硬度),Ca2+释放,牙重矿化 (SEM/EDS) 和细胞活力 (CCK-8测定).
主要成果:
- 组A (45wt.%A-MSNs + 15wt.%Pchi/ACP) 显示了最高的机械强度.
- D组 (15wt.% Pchi/ACP) 显示出最显著的牙重矿化.
- B组表现出对pH反应的Ca2+释放,在较低的pH下释放量更高.
- 所有组都超过了50%的双键转换,并在7天内保持了>75%的细胞活力.
结论:
- 一种含有45%重量%A-MSNs和15%重量%Pchi/ACP的复合制剂显著提高了机械强度.
- 15%重量的Pchi/ACP配方提供了最大的重矿化效果.
- 组B提供了机械性能和重矿化潜力的平衡,与pH响应的Ca2+释放.
- 所有测试的配方都是牙科应用的生物相容性.
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