基因对DNA甲基化和肥胖度之间的关联的影响:来自双胞胎研究设计的见解
Xuanming Hong1,2, Hui Cao1,2, Weihua Cao1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Cell & bioscience
|July 23, 2025
概括
遗传因素显著影响DNA甲基化 (DNAm) 和肥胖的联系,这可能解释了为什么与肥胖相关的DNAm标记通常不会复制. 未来的研究必须考虑这些遗传影响.
科学领域:
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 肥胖问题研究研究
背景情况:
- 肥胖和DNA甲基化 (DNAm) 具有共同的遗传影响.
- 之前的研究已经确定了超过一千个与肥胖相关的DNAm位点 (CpG),但往往忽视了遗传因素.
- 有限的研究已经探索了肥胖症中遗传影响和DNAm之间的相互作用.
研究的目的:
- 研究全基因组DNA甲基化和肥胖指数 (BMI,WC,WHR) 之间的表型,遗传和环境相关性.
- 确定遗传因素对DNAm与肥胖之间的关联有何影响.
- 评估遗传影响对与肥胖相关的DNAm标记物的可复制性的影响.
主要方法:
- 利用来自中国国家双胞胎登记处的1,074名双胞胎的数据.
- 采用双变量结构方程模型 (SEM) 来分析相关性.
- 在全种群中进行了关联研究和单胞胎 (MZ) 双对设计,以控制遗传效应.
主要成果:
- DNAm与肥胖指数之间的全基因组相关性通常很小.
- 具有高表型相关性的CPG显示出显著的遗传影响 (平均遗传相关性为0.23-0.24).
- 遗传因素主要推动了具有高表型和遗传相关性的CpG的关联;在MZ双对分析中,这些关联没有显著意义.
结论:
- 显著的遗传影响是DNA甲基化和肥胖之间的关系的基础.
- 遗传因素可能解释了与肥胖相关的DNAm标记物观察到的低可复制性.
- 遗传影响在未来的mDNA和肥胖研究中需要仔细考虑.
更多相关视频
相关概念视频
Behavioral Genetics and Its Designs
518
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
518
Epigenetic Regulation
3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.1K
Genomic Imprinting and Inheritance
35.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.3K
Gene-Environment Interactions
483
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
483
Human Genetics
727
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
727
Polygenic Traits
66.5K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.5K


