在孕前症 (有并发症和没有并发症) 和正常怀孕中的尿内氨酸度
Anastasia Lumentut1, Adhi Pribadi1, Amillia Siddiq1
1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia.
概括
在孕前症中,尿液内林水平升高,表明脏受损. 在复杂的孕前症中,氨酸度较高表明它可能作为脏干扰严重程度的生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 产科 产科 产科 产科 产科
- 生物标志物发现发现
背景情况:
- 孕前症破坏了血管源-抗血管源平衡,导致脏损伤和质内皮质.
- 氨酸,一个 podocyte 蛋白质,是潜在的早期生物标志物,用于与孕前相关的急性损伤.
- 这项研究研究了在有并发症和没有并发症的孕前症下与正常怀孕相比,尿道内的研究.
研究的目的:
- 评估孕妇患有先兆子 (并发症和无并发症) 和正常怀孕的尿内尼弗林度.
- 评估尿内的潜力,作为预先怀孕前的参与的早期生物标志物.
- 为了将尿内林水平与孕前并发症的严重程度相关联.
主要方法:
- 对120名孕妇进行了前性,横截面的观察性研究.
- 分类为三组:正常怀孕,没有并发症的孕前,并发症的孕前.
- 通过ELISA测量尿中尼弗林度;使用SPSS进行统计分析.
主要成果:
- 在所有组中,母亲的平均年龄相似.
- 与正常怀孕 (1.11±0.356;P<0.0001) 相比,在孕前症组 (4.59±1.051和9.12±1.225) 的尿内尼林度显著更高.
- 没有并发症的孕前的高水平表明早期的球损伤.
结论:
- 在孕前症中,尿中氨酸水平显著升高.
- 在复杂的孕前症病例中观察到较高的尼林度.
- 尿内林显示出作为评估先兆子症关严重程度的生物标志物的潜力.
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