哺乳,遗传易感性,以及后代在晚年生活中的2型糖尿病
Ying Hu1,2,3, Hao Ma3, Xuan Wang3
1Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Obesity (Silver Spring, Md.)
|July 24, 2025
概括
哺乳与后代患2型糖尿病 (T2D) 的风险降低有关. 这种保护作用与遗传倾向相互作用,进一步影响T2D风险.
科学领域:
- 流行病学 流行病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2D) 是一个日益严重的全球健康问题.
- 遗传易感性在T2D的发展中起作用.
- 早期生活因素,如母乳养对T2D风险的影响需要进一步阐明.
研究的目的:
- 为了前性地研究母乳养与后代T2D发病风险之间的关联.
- 研究母乳养和遗传易感性对T2D风险的综合影响.
主要方法:
- 利用了来自364,562名没有T2D流行的参与者的英国生物库数据.
- 用Cox的比例危险模型来评估母乳养与T2D事件的关联.
- 分析了母乳养与T2D遗传风险评分 (T2D-GRS) 之间的相互作用效应.
主要成果:
- 在12年的时间里,记录了12795例T2D病例.
- 曾经母乳养与降低了6%的T2D风险相关 (HR=0.94,95%CI:0.89-0.99).
- 在母乳养和T2D-GRS之间发现了显著的乘法和加法相互作用,在从未哺乳过的具有高遗传风险的个体中,T2D风险更强.
结论:
- 哺乳与后代发生T2D风险降低有关.
- 母乳养显示了与T2D遗传风险评分的乘法和加法相互作用,从而改变T2D风险.
- 研究结果强调母乳养是预防T2D的潜在可修改因素,特别是在基因易受感染的个体中.
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