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具有抗菌和微环境重塑能力的3D打印负波桑比率复合支架,用于改善椎间盘退化

Zhou Sha¹, Yichao Ma², Wei Li¹

¹Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 200092, China.

Advanced healthcare materials

|July 24, 2025

概括

这项研究介绍了一种新的3D打印脚手架,具有负波桑值.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
再生医学是一种再生医学.

背景情况:

椎间盘退化 (IDD) 涉及炎症和核脉 (NP) 细胞功能障碍.
目前IDD的治疗方法缺乏有效的策略来解决细胞失衡和机械故障.

研究的目的:

开发一种3D打印的脚手架,具有负波桑比率 (NPR) 属性,用于椎间盘组织工程.
将抗炎和抗氧化功能纳入脚手架,以增强治疗效果.
评估NPR支架在保护细胞核和减轻IDD中的有效性.

主要方法:

用于3D打印NPR脚手架的复合墨水 (凝甲酸和聚乙烯糖醇二酸) 的制造.
有限元模拟来分析压力分布和脚手架的机械反应.
用酸修饰表面,以获得抗氧化,抗炎和抗菌的特性.
在脂质体内封装黄素和TT-10以控制药物释放.
在炎症条件下对细胞核的体外研究.
在IDD的老鼠模型中体内植入脚手架.

主要成果:

在模拟的膨胀条件下,NPR支架显示出均的应力分布,并抑制了NP突起.
酸涂层提供了抗氧化,抗炎和抗菌作用.
在炎症条件下,脂质体封装药物有效释放,保护NP细胞.
在体内研究表明,NPR支架保持了圆盘高度,并减轻了大鼠的IDD进展.

结论:

开发的3D打印NPR支架与集成药物输送提供了一个有前途的治疗策略,对椎间盘退化.
这种创新的支架系统解决了IDD的机械和生物方面的问题.
进一步的研究可能会导致对脊髓疾病的先进组织工程解决方案.

关键词:

通过3D打印进行3D打印.炎症调节炎症调节的作用椎间盘退化椎间盘退化多功能水凝脚手架.有负的波森比率.

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