活跃的恶性瘤不会影响急性四肢缺血患者的四肢挽救和再封闭:单中心体验
Edoardo Pasqui1, Samira Bucelli1, Leonardo Pasquetti1
1Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy.
Vascular medicine (London, England)
|July 24, 2025
概括
针对急性四肢缺血症 (ALI) 进行重血管化的活跃恶性瘤患者面临更高的死亡风险. 然而,肢体救援和再封闭率是可比的,这表明再血管化仍然是合适的.
科学领域:
- 血管外科 血管外科
- 在瘤学瘤学.
- 临床结果研究研究
背景情况:
- 急性四肢缺血症 (ALI) 对四肢活力和患者存活存在重大风险.
- 同时活跃恶性瘤对ALI治疗结果的影响需要进一步阐明.
研究的目的:
- 评估活跃恶性瘤对ALI下肢再血管化的患者死亡率,肢体挽救和通透性损失的影响.
- 确定该患者群体中不良结果的预测因素.
主要方法:
- 在7年内对296名ALI患者进行了再血管化治疗的回顾性分析.
- 在ALI诊断时分为具有和没有活跃恶性瘤的群体.
- 卡普兰-梅尔和考克斯对生存,肢体救援和再封闭的比例危险分析.
主要成果:
- 活跃恶性瘤存在于12.8%的患者中.
- 虽然30天的结果相似,但患有恶性瘤的患者的长期存活率明显降低 (p=0.005).
- 活跃恶性瘤独立预测了更高的死亡率 (OR 3.321,p=0.01),但没有肢体救援或再封闭.
结论:
- 活跃的恶性瘤是ALI患者在再血管化后死亡率增加的重要独立预测因素.
- 肢体救援和再封闭率不会受到活跃恶性瘤的不利影响.
- 在临床上显示时,应考虑对ALI患者具有活跃恶性瘤进行再血管化.
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