酒精使用障碍和并发性抑郁症状中的psilocybin:可行性随机临床试验的结果
Amandine Luquiens1, Dahbia Belahda2, Carine Graux2
1University Montpellier, Department of Addiction, CHU Nîmes, Nîmes, France, CESP, University Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
Addiction (Abingdon, England)
|July 24, 2025
概括
松素辅助心理治疗在治疗酒精使用障碍 (AUD) 和抑郁症方面表现有前途. 在一项试点研究中,高剂量的psilocybin显著改善了禁欲率,并减少了渴望.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
背景情况:
- 酒精使用障碍 (AUD) 是一个重要的健康问题,治疗疗效不一致.
- 脱毒后的抑郁症增加了AUD患者复发的风险.
- 西正在作为AUD的新型治疗剂进行研究.
研究的目的:
- 评估松素辅助心理治疗的可行性,可接受性和初步疗效.
- 为了评估psilocybin作为辅助治疗患者的伴随性AUD和抑郁症.
- 为了确定psilocybin在这个患者群体中的安全概况.
主要方法:
- 一项随机,双盲,安慰剂控制的试点研究,涉及30名患有严重AUD和抑郁症的成年人.
- 参与者接受了两次25毫克或1毫克psilocybin作为标准护理的附加剂.
- 结果包括可行性,酒精使用,复发率,抑郁症得分,渴望和安全性.
主要成果:
- 与1毫克组相比,25毫克松素组表现出明显更高的戒断率 (55%对11%) 和减少的饮酒日和渴望.
- 在高剂量 псилоцибин组中,复发率较低 (35%对50%).
- 治疗被发现是可行的,可以接受的和安全的,没有基于抗抑郁药的有效性差异.
结论:
- 松素辅助心理治疗是一种可行,可接受和安全的治疗选择,用于最近解毒的患者,患有并发性AUD和抑郁症.
- 高剂量的psilocybin显示了初步有效性,改善了禁欲和减少了这种人群的渴望.
- 需要进一步的研究,以在更大的试验中证实这些发现.
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