前沟通动脉的患者特异性血液动力学分析:使用基于MRI的计算模拟对单侧和双侧血管模型进行比较评估
Zhen-Ye Chen1, Te-Chang Wu2,3, Tzu-Ching Shih4,5
1Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.
概括
前沟通动脉 (AComA) 中精确的血液动力学需要考虑双边流入. 计算流体动力学模型从患者特定的数据中获益,用于精确的评估和治疗计划.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 流体动力学 流体动力学
背景情况:
- 前沟通动脉 (AComA) 是威利斯圆的关键组成部分,影响大脑血液流动.
- 了解其血液动力学对于评估脑血管疾病和规划干预措施至关重要.
研究的目的:
- 通过患者特定的计算流体动力学 (CFD) 模拟,研究双边流入和血管几何学对AComA血液动力学的影响.
- 评估CFD模型在AComA.A.内预测血流和剪切应力的准确性.
主要方法:
- 从四名受试者获得磁共振血管学 (MRA) 数据,以创建针对患者的CFD模型.
- 使用相对比MRA进行流速测量,并将MRA衍生的波形用于脉冲式流量模拟.
- 假设模拟的刚性墙壁,层状和不可压缩的流量条件.
主要成果:
- 模拟的内动脉速度与MRA测量有很强的相关性 (>90%).
- 入口阶段延迟对时间平均壁切削应力 (TAWSS) 的影响很小.
- 在明显的前脑动脉 (ACA) 不对称的情况下,观察到显著的TAWSS变化 (>90%),突出显示了双边流入的重要性.
结论:
- 双边ACA流入对于准确的TAWSS估计至关重要,特别是在解剖对称的情况下.
- 结合双边流入的患者特定的CFD模型增强了ACOMA的血液动力学评估.
- 这些发现支持使用个性化的CFD建模来改进ACOMA评估和治疗策略.
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